Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome

  title={Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome},
  author={Thomas J. Mcgarrity and Laurie P. Peiffer and Christopher I. Amos and Marsha L. Frazier and Margaret G Ward and Mary K. Howett},
  journal={American Journal of Gastroenterology},
OBJECTIVE:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant hamartomatous polyposis syndrome. Affected individuals are at risk for intestinal and extraintestinal malignancies. Prostaglandins and polyamines are small molecules believed to be important in tumor formation and growth. Cyclooxygenase (COX) and ornithine decarboxylase (ODC) are key enzymes in the prostaglandin and polyamine biosynthetic pathways, respectively. The aim of this study was to measure and compare COX-1 and COX-2… CONTINUE READING


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