Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome

@article{Mcgarrity2003OverexpressionOC,
  title={Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome},
  author={Thomas J. Mcgarrity and Laurie P. Peiffer and Christopher I. Amos and Marsha L. Frazier and Margaret G Ward and Mary K. Howett},
  journal={American Journal of Gastroenterology},
  year={2003},
  volume={98},
  pages={671-678}
}
OBJECTIVE:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant hamartomatous polyposis syndrome. Affected individuals are at risk for intestinal and extraintestinal malignancies. Prostaglandins and polyamines are small molecules believed to be important in tumor formation and growth. Cyclooxygenase (COX) and ornithine decarboxylase (ODC) are key enzymes in the prostaglandin and polyamine biosynthetic pathways, respectively. The aim of this study was to measure and compare COX-1 and COX-2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Role of LKB1 in lung cancer development

British Journal of Cancer • 2008
View 1 Excerpt

Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2008

References

Publications referenced by this paper.
Showing 1-10 of 51 references

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.

The New England journal of medicine • 2000
View 6 Excerpts
Highly Influenced

Peutz-Jeghers syndrome (February 2001). In: GeneClinics Clinical Genetic Information Resource (database online)

CI Amos, ML Frazier, TJ. McGarrity
http://www.geneclinics.org • 2001

Peutz-Jeghers syndrome

American Journal of Gastroenterology • 2000

Similar Papers

Loading similar papers…