Overexpression of CyclinG 1 Moderately Accelerates G 1 / S Transition in Neonatal Rat Cardiomyocytes

@inproceedings{Liu2010OverexpressionOC,
  title={Overexpression of CyclinG 1 Moderately Accelerates G 1 / S Transition in Neonatal Rat Cardiomyocytes},
  author={Zhipei Liu and Shijing Yue and Xiaobo Chen and Thomas Kubin and Thomas Braun},
  year={2010}
}
Rationale: Polyploidy and multinucleation are characteristic features of mammalian cardiomyocytes, which develop shortly after birth when most differentiated cardiomyocytes become acytokinetic. Cardiac overload and hypertrophy further increase the degree of polyploidy of cardiomyocytes, suggesting a role in cell type–specific responses to physiological and… CONTINUE READING