Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice.

Abstract

BACKGROUND AND PURPOSE The role of copper, zinc-superoxide dismutase (CuZn-SOD) in hippocampal injury after transient global ischemia was studied using transgenic (Tg) mice and wild-type littermates. METHODS Global ischemia was induced by bilateral common carotid artery occlusion. The hemisphere with the hypoplastic posterior communicating artery was… (More)

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