Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.

@article{Cui2016OverexpressionOC,
  title={Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.},
  author={Feiyi Cui and Wen-tao Wang and Duoguang Wu and Xiao-shun He and Jingjing Wu and Min Qi Wang},
  journal={Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico},
  year={2016},
  volume={18 7},
  pages={722-7}
}
Lung cancer, the most common malignancy, is still the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) accounts for 80 % of all lung cancers. Recent studies showed Cathepsin L (CTSL) is overexpressed in various cancerous tissues; however, the association between CTSL expression and EGFR-TKI resistance remains unknown. In this study, we investigated the expression of CTSL in lung cancer specimens and matched normal tissues by quantitative real-time PCR and IHC… CONTINUE READING

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