Corpus ID: 49225935

Overexpression of CST 4 promotes gastric cancer aggressiveness by activating the ELFN 2 signaling pathway

  title={Overexpression of CST 4 promotes gastric cancer aggressiveness by activating the ELFN 2 signaling pathway},
  author={Yi Zhang and Jing Zhang and Hong-Jie Song and Da Wei Li},
Gastric cancer is one of the most lethal malignancies of gastrointestinal cancer and its prognosis remains dismal because of the paucity of effective therapeutic targets. Here, we show that cystatin 4 (CST4) is markedly upregulated in gastric cancer cell lines and clinical tissues. Ectopic expression of CST4 in gastric cancer cells promoted proliferation, migration, and invasion of gastric cancer cells in vitro. Furthermore, CST4 overexpression significantly promoted the tumorigenicity of… Expand

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