Corpus ID: 49225935

Overexpression of CST 4 promotes gastric cancer aggressiveness by activating the ELFN 2 signaling pathway

@inproceedings{Zhang2017OverexpressionOC,
  title={Overexpression of CST 4 promotes gastric cancer aggressiveness by activating the ELFN 2 signaling pathway},
  author={Yi Zhang and Jing Zhang and Hong-Jie Song and Da Wei Li},
  year={2017}
}
Gastric cancer is one of the most lethal malignancies of gastrointestinal cancer and its prognosis remains dismal because of the paucity of effective therapeutic targets. Here, we show that cystatin 4 (CST4) is markedly upregulated in gastric cancer cell lines and clinical tissues. Ectopic expression of CST4 in gastric cancer cells promoted proliferation, migration, and invasion of gastric cancer cells in vitro. Furthermore, CST4 overexpression significantly promoted the tumorigenicity of… Expand

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References

SHOWING 1-10 OF 20 REFERENCES
DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway
TLDR
A novel role of DDX5 in gastric cancer cell proliferation via the mTOR pathway is revealed and it is observed thatDDX5 was significantly up-regulated in Gastric cancer tissues compared with the paired adjacent normal tissues. Expand
Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway
TLDR
It is shown that Tripartite motif containing 14(TRIM14) is markedly up-regulated in TSCC cell lines and clinical tissues and it is demonstrated that TRIM14 enhanced TSCC aggressiveness by activating NF-κB signaling. Expand
Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis
TLDR
The results showed that CST6 suppressed the proliferation, colony formation, migration and invasion of breast cancer cells, and established secreted CST6 as a bona fide suppressor of Breast cancer osteolytic metastasis. Expand
Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis
TLDR
It is found that CST1 was generally upregulated in breast cancer at both mRNA and protein level, and high CST1 expression is negatively correlated with survival of breast cancer patients. Expand
FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL
TLDR
Findings indicate that FOXM1 may play an important role in advancing lung adenocarcinoma progression, and inhibition of FOXM 1-SNAIL signaling may present an ideal target for future treatment. Expand
MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
TLDR
This study provides novel insights into the tumor progression associated with MFN2 deficiency and suggests that the importance of mTORC2 inhibitor in the treatment ofMFN2 downregulated cancer patients is suggested. Expand
MicroRNA-34a/EGFR axis plays pivotal roles in lung tumorigenesis
TLDR
The findings suggest that miR-34a inhibits NSCLC tumor growth and metastasis through targeting EGFR, and siRNA knockdown of EGFR can inhibit cell proliferation, promote apoptosis and arrest cell-cycle progression. Expand
Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer
TLDR
Results suggest that high CST1 expression may be involved in autophagic induction and protects from AF-induced cell death by inhibition of ROS generation through the regulation of GR activity. Expand
Regulation of cathepsin B and L expression in vitro in gastric cancer tissues by egg cystatin.
TLDR
The experiment demonstrated that the cysteine peptidases cathepsins B and L may be useful for the early detection of gastric cancer and suggested that addition of egg white cystatin reduces the activities ofCathepsin B andL to that of non-cancerous values. Expand
Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer.
TLDR
CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. Expand
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