Overexpression of CSF-1R in nasopharyngeal carcinoma.


BACKGROUND Tumor-associated macrophages play a significant role in tumor progression. CSF-1/CSF-1R is one of the most primary regulators of macrophage physiology in immune system. The expression of CSF-1/CSF-1R in nasopharyngeal carcinoma is unclear. OBJECTIVES The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1/CSF-1R in nasopharyngeal carcinoma. MATERIALS AND METHODS Diagnostic tissues from 56 nasopharyngeal carcinoma patients and 32 nasopharyngitis patients were evaluated retrospectively by immunohistochemical analysis for the expression of CSF-1R. RESULTS Significant differences of CSF-1R expression exists between nasopharyngeal carcinoma patients and nasopharyngitis patients (p<0.001). However, there is no relevance between CSF-1R and worse survival.

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@article{Huang2015OverexpressionOC, title={Overexpression of CSF-1R in nasopharyngeal carcinoma.}, author={Li Huang and Ximing Xu and Yanrong Hao and JiaXin Chen and Lei Li and Junping Cheng and Zhaohong Chen and Wuqing Liang and Jiao Yang and Wen Ao and Xin Hao and Weiwei Gao}, journal={Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie}, year={2015}, volume={56 4}, pages={1279-83} }