Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma

  title={Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma},
  author={Dimitrios D. Karavias and Ioannis Maroulis and Helen E Papadaki and Charalambos Gogos and Stavros K. Kakkos and Dionissios Karavias and Vasiliki Bravou},
  journal={Journal of Gastrointestinal Surgery},
Genomic instability is a common feature in hepatocellular carcinoma. Deregulation of replication licensing factors has been shown to trigger DNA damage response contributing to genomic instability. Overexpression of DNA replication licensing factors chromatin licensing and DNA replication factor 1 (CDT1) and minichromosome maintenance complex component 7 (MCM7) has been previously reported in several human cancers. The aim of the present study was to evaluate the expression and prognostic… CONTINUE READING
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Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma

BioMed research international • 2014
View 3 Excerpts
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A p53-dependent checkpoint pathway prevents rereplication.

Molecular cell • 2003
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MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver • 2012

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