Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

@inproceedings{Hiscox2012OverexpressionOC,
  title={Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan},
  author={Stephen E. Hiscox and Bedanta Baruha and Chris Tyler Smith and Rebecca Bellerby and Lindy Goddard and Nicola J. Jordan and Zaruhi Poghosyan and Robert Ian Nicholson and Peter J. Barrett-Lee and Julia M. W. Gee},
  booktitle={BMC Cancer},
  year={2012}
}
Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases. Breast cancer cell models reveal that endocrine resistance is accompanied by a gain in aggressive behaviour driven in part through altered growth factor receptor signalling, particularly involving erbB family receptors. Recently we identified that CD44, a transmembrane cell adhesion receptor known to interact with… CONTINUE READING