Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK Cells in Acute Myeloid Leukemia.

@article{SandovalBorrego2016OverexpressionOC,
  title={Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK Cells in Acute Myeloid Leukemia.},
  author={Daniela Sandoval-Borrego and Martha C Moreno-Lafont and Ernesto Antonio V{\'a}zquez-S{\'a}nchez and Adriana Guti{\'e}rrez-Hoya and Rub{\'e}n L{\'o}pez-Santiago and Laura Arcelia Montiel-Cervantes and Maricela Ram{\'i}rez-Salda{\~n}a and Jorge Vela-Ojeda},
  journal={Archives of medical research},
  year={2016},
  volume={47 1},
  pages={55-64}
}
BACKGROUND AND AIMS Natural killer (NK) cells are innate immune system cells that are actively involved in immune-surveillance of tumor cells. Recognition of tumors by NK cells occurred via natural cytotoxicity receptors and killer cell immunoglobulin-like receptors. Some ligands of the activating receptors seem to be present on malignant cells from patients with acute myeloid leukemia. The aim of the study was to evaluate the expression of activating receptors such as NKG2D, DNAM-1, NKp30, and… CONTINUE READING
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