Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence

  title={Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence},
  author={D. Wiens F. G. Hawksworth and Lakshmi Ravindranath and Yongmei Chen and Bungo Furusato and Isabell A. Sesterhenn and David G. Mcleod and Shiv Srivastava and Gyorgy Petrovics},
  journal={Prostate Cancer and Prostatic Diseases},
Alterations of chromosome 8, including amplification at 8q24 harboring the C-MYC oncogene, have been noted as one of the most common chromosomal abnormalities in prostate cancer (CaP) progression. However, the frequency of C-MYC alterations in CaP has remained uncertain. A recent study, using a new anti-MYC antibody, described prevalent upregulation of nuclear C-MYC protein expression as an early oncogenic alteration in CaP. Further, we have recently reported regulation of C-MYC expression by… CONTINUE READING


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Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic agents

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