Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: effects of AT1 blockade with losartan.

@article{Fortuo1998OverexpressionOB,
  title={Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: effects of AT1 blockade with losartan.},
  author={Mar{\'i}a Antonia Fortu{\~n}o and Susana Ravassa and J. C. Etayo and Javier D{\'i}ez},
  journal={Hypertension},
  year={1998},
  volume={32 2},
  pages={280-6}
}
An association of increased apoptosis with overactivity of the local angiotensin-converting enzyme has been reported in cells from the left ventricle of adult rats with spontaneous hypertension (SHR). To gain insight into the regulation of cardiac apoptosis in arterial hypertension, we investigated the expression of the proteins Bcl-2 (an inhibitor of apoptosis) and Bax (an inducer of apoptosis) in the left ventricle of 30-week-old normotensive Wistar-Kyoto rats (WKY), SHR, and SHR treated with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Apoptosis in the failing human heart.

The New England journal of medicine • 1997

Similar Papers

Loading similar papers…