Overexpression of BMI-1 Promotes Cell Growth and Resistance to Cisplatin Treatment in Osteosarcoma

@inproceedings{Wu2011OverexpressionOB,
  title={Overexpression of BMI-1 Promotes Cell Growth and Resistance to Cisplatin Treatment in Osteosarcoma},
  author={Zhihong Wu and Li Min and Dafu Chen and DongSheng Hao and Yuanhui Duan and Guixing Qiu and Yipeng Wang},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND BMI-1 is a member of the polycomb group of genes (PcGs), and it has been implicated in the development and progression of several malignancies, but its role in osteosarcoma remains to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS In the present study, we found that BMI-1 was overexpressed in different types of osteosarcomas. Downregulation of BMI-1 by lentivirus mediated RNA interference (RNAi) significantly impaired cell viability and colony formation in vitro and tumorigenesis in… CONTINUE READING

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