Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

@article{Martinou1994OverexpressionOB,
  title={Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia},
  author={J. Martinou and M. Dubois-Dauphin and J. Staple and I. Rodr{\'i}guez and J. Huarte},
  journal={Neuron},
  year={1994},
  volume={13},
  pages={1017-1030}
}
  • J. Martinou, M. Dubois-Dauphin, +2 authors J. Huarte
  • Published 1994
  • Biology, Medicine, Computer Science
  • Neuron
  • Naturally occurring cell death (NOCD) is a prominent feature of the developing nervous system. During this process, neurons express bcl-2, a major regulator of cell death whose expression may determine whether a neuron dies or survives. To gain insight into the possible role of bcl-2 during NOCD in vivo, we generated lines of transgenic mice in which neurons overexpress the human BCL-2 protein under the control of the neuron-specific enolase (NSE) or phosphoglycerate kinase (PGK) promoters. BCL… CONTINUE READING
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