Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia.

@article{Martinou1994OverexpressionOB,
  title={Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia.},
  author={J C Martinou and Michel L Dubois-Dauphin and Julie K. Staple and Iv{\'a}n Rodr{\'i}guez and Harald Frankowski and Marc Missotten and Patrizia Albertini and Dominique Talabot and Stefan Catsicas and Claudio Pietra},
  journal={Neuron},
  year={1994},
  volume={13 4},
  pages={1017-30}
}
Naturally occurring cell death (NOCD) is a prominent feature of the developing nervous system. During this process, neurons express bcl-2, a major regulator of cell death whose expression may determine whether a neuron dies or survives. To gain insight into the possible role of bcl-2 during NOCD in vivo, we generated lines of transgenic mice in which neurons overexpress the human BCL-2 protein under the control of the neuron-specific enolase (NSE) or phosphoglycerate kinase (PGK) promoters. BCL… CONTINUE READING
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