Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

@article{Martinou1994OverexpressionOB,
  title={Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia},
  author={Jean-Claude Martinou and Michel Dubois‐Dauphin and Julie K. Staple and Ivan Rodriguez and Harald Frankowski and Marc Missotten and P Albertini and Dominique Talabot and Stefano Catsicas and Claudio Pietra and J. Huarte},
  journal={Neuron},
  year={1994},
  volume={13},
  pages={1017-1030}
}
Naturally occurring cell death (NOCD) is a prominent feature of the developing nervous system. During this process, neurons express bcl-2, a major regulator of cell death whose expression may determine whether a neuron dies or survives. To gain insight into the possible role of bcl-2 during NOCD in vivo, we generated lines of transgenic mice in which neurons overexpress the human BCL-2 protein under the control of the neuron-specific enolase (NSE) or phosphoglycerate kinase (PGK) promoters. BCL… 
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Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice
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Overexpression of Bcl-2 Reduces Sex Differences in Neuron Number in the Brain and Spinal Cord
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