Overexpression of B-type cyclins alters chromosomal segregation

Abstract

To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype. Screening in this strain of a yeast genomic library cloned into a high copy vector led us to identify, among the clones generating 100% of sectoring… (More)
DOI: 10.1038/sj.onc.1205257

6 Figures and Tables

Topics

  • Presentations referencing similar topics