Overexpression of Atg5 in mice activates autophagy and extends lifespan

@article{Pyo2013OverexpressionOA,
  title={Overexpression of Atg5 in mice activates autophagy and extends lifespan},
  author={Jong-Ok Pyo and Seung-Min Yoo and Hye-Hyun Ahn and Jihoon Nah and Se-hoon Hong and Tae-In Kam and Sunmin Jung and Yong-Keun Jung},
  journal={Nature Communications},
  year={2013},
  volume={4}
}
Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of mice by 17.2%. We demonstrate that moderate overexpression of Atg5 in mice enhances autophagy, and that Atg5 transgenic mice showed anti-ageing phenotypes, including leanness, increased insulin sensitivity and improved motor function… 

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