Overexpression of Aspergillus nidulans α-1,3-glucan synthase increases cellular adhesion and causes cell wall defects.

@article{He2018OverexpressionOA,
  title={Overexpression of Aspergillus nidulans α-1,3-glucan synthase increases cellular adhesion and causes cell wall defects.},
  author={Xiaoxiao He and Shengnan Li and Susan G W Kaminskyj},
  journal={Medical mycology},
  year={2018},
  volume={56 5},
  pages={645-648}
}
Alpha-1,3-glucan is important for pathogenesis by Aspergillus fumigatus, but the mechanism is unclear since the deletion has no hyphal phenotype. We dissected the roles of A. nidulans α-1,3-glucan in constitutive overexpression strains. Constitutive high-level α-1,3-glucan synthase activity increased hyphal wall thickness, but colonies grew slowly and… CONTINUE READING