Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

@article{Page2000OverexpressionOA,
  title={Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.},
  author={Carmen Page and Hsingchi J Lin and Yue-ling Jin and Valerie P. Castle and Gabriel N{\'u}{\~n}ez and Melinda Gingman Huang and J Lin},
  journal={Anticancer research},
  year={2000},
  volume={20 1A},
  pages={407-16}
}
The AKT oncogenes are amplified or AKT kinase activity is constitutively elevated in several types of human malignancy. We sought to determine whether AKT might play a role in the development of resistance to apoptosis induced by chemotherapy. We showed that ovarian cancer cells either overexpressing constitutively active Akt/AKT1 or containing AKT2 gene amplification were highly resistant to paclitaxel than cancer cells express low AKT levels. The Akt/AKT1 clones also contained higher levels… CONTINUE READING

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