Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

  title={Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.},
  author={Carmen Page and Hsingchi J Lin and Yue-ling Jin and Valerie P. Castle and Gabriel N{\'u}{\~n}ez and Melinda Gingman Huang and J Lin},
  journal={Anticancer research},
  volume={20 1A},
The AKT oncogenes are amplified or AKT kinase activity is constitutively elevated in several types of human malignancy. We sought to determine whether AKT might play a role in the development of resistance to apoptosis induced by chemotherapy. We showed that ovarian cancer cells either overexpressing constitutively active Akt/AKT1 or containing AKT2 gene amplification were highly resistant to paclitaxel than cancer cells express low AKT levels. The Akt/AKT1 clones also contained higher levels… CONTINUE READING

From This Paper

Topics from this paper.
89 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 89 extracted citations

Similar Papers

Loading similar papers…