Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance.

Abstract

Obese obob mice with strong overexpression of the human apolipoprotein C1 (APOC1) exhibit excessive free fatty acid (FFA) and triglyceride (TG) levels and severely reduced body weight (due to the absence of subcutaneous adipose tissue) and skin abnormalities. To evaluate the effects of APOC1 overexpression on hepatic and peripheral insulin sensitivity in a… (More)

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@article{Muurling2004OverexpressionOA, title={Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance.}, author={Martin Muurling and Anita M. van den Hoek and Ronald P Mensink and Hanno Pijl and Johannes Anthonius Romijn and Louis M. Havekes and Peter Jacobus Voshol}, journal={Journal of lipid research}, year={2004}, volume={45 1}, pages={9-16} }