Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients.

@article{He2010OverexpressionOA,
  title={Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients.},
  author={L He and H Zhao and B-K Li and Lan-jun Zhang and M-Z Liu and H-f Kung and X Guan and X-w Bian and Y X Zeng and Dong Xie},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2010},
  volume={21 8},
  pages={1675-81}
}
BACKGROUND The amplified in breast cancer 1 (AIB1) gene has been considered to play an oncogenic role in human cancers, but its clinical/prognostic significance in non-small-cell lung cancer (NSCLC) is still unclear. PATIENTS AND METHODS The methods of immunohistochemistry and FISH were utilized to examine protein expression and amplification of AIB1 in 230 informative surgically resected NSCLCs and in 30 samples of normal lung tissues. RESULTS Overexpression and amplification of AIB1 were… CONTINUE READING