Overexpression of A3 adenosine receptors in smooth, cardiac, and skeletal muscle is lethal to embryos.

@article{Zhao2002OverexpressionOA,
  title={Overexpression of A3 adenosine receptors in smooth, cardiac, and skeletal muscle is lethal to embryos.},
  author={Zhihui Zhao and Ron Yaar and D. W. Ladd and Leah M Cataldo and Katya Ravid},
  journal={Microvascular research},
  year={2002},
  volume={63 1},
  pages={61-9}
}
The profile of expression of the A3 adenosine receptor (A3AR) and its importance during embryo development were explored. To this end, different ages of mouse embryos (8.5 days and older) were subjected to in situ hybridization with an A3AR riboprobe. No expression was found in any embryonic tissue except for the aorta and heart of 15.5-day embryos. To investigate further the role of the A3AR gene in development, we overexpressed this gene in A3AR knockout and wild-type mice by using the SM22… CONTINUE READING