Overexpression of 5-lipoxygenase increases the neuronal vulnerability of PC12 cells to Aβ₄₂.

@article{Wang2011OverexpressionO5,
  title={Overexpression of 5-lipoxygenase increases the neuronal vulnerability of PC12 cells to Aβ₄₂.},
  author={Ze-jian Wang and Bin Zhou and Wen-wei Mao and Ming Yin},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  year={2011},
  volume={131 12},
  pages={
          1843-53
        }
}
  • Ze-jian Wang, Bin Zhou, +1 author Ming Yin
  • Published in
    Yakugaku zasshi : Journal of…
    2011
  • Chemistry, Medicine
  • 5-Lipoxygenase (5-LOX), which is believed to be a major source of oxidative stress, participates in somatostatin-receptor transmembrane signaling in the central nervous system. We used the Tet-On inducible expression system in PC12 cells to obtain cell lines with reproducible, stable 5-LOX expression levels to study its function. Cell apoptosis rates induced by Aβ(42) were determined using an apo-BrdDU kit. Lipid peroxide, antioxidant enzyme, and caspase-3 activities were evaluated with… CONTINUE READING

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