Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.

@article{Li2005OverexpressionO5,
  title={Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.},
  author={Ning Li and Sandeep Sood and Su Wang and Mingzhu Fang and Peng Wang and Zheng Sun and Chung S Yang and Xiaoxin Luke Chen},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 5},
  pages={
          2089-96
        }
}
PURPOSE Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. However, it is unknown whether the 5-lipoxygenase (5-Lox) pathway contributes to oral carcinogenesis, and whether combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention. EXPERIMENTAL DESIGN 5-Lox expression was examined in 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 59 CITATIONS

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Transgenic cyclooxygenase-2 overexpression sensitizes Clinical Cancer

  • K Muller-Decker, G Neufang, I Berger, M Neumann, F Marks, G. Furstenberger
  • Research Research. on April
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…