Overexpression of 5-Lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis

@article{Chen2004OverexpressionO5,
  title={Overexpression of 5-Lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis},
  author={Xiaoxin Chen and Su Wang and N. Wu and S. Sood and P. Wang and Zhe Jin and D. Beer and T. Giordano and Y. Lin and W. Shih and R. Lubet and C. Yang},
  journal={Clinical Cancer Research},
  year={2004},
  volume={10},
  pages={6703 - 6709}
}
Purpose: Aberrant arachidonic acid (AA) metabolism, especially through the cyclooxygenase (Cox) and 5-lipoxygenase (5-Lox) pathways, has been suggested to play an important role in the development of esophageal adenocarcinoma (EAC). The purpose of this study was to investigate the expression of 5-Lox in EAC of a rat model and in human samples as well as the chemopreventive effects of zileuton (a specific 5-Lox inhibitor) and celecoxib (a specific Cox2 inhibitor) in the rat EAC model… Expand
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It is shown that both 5-Lox and Cox2 played important roles in oral carcinogenesis at the post-initiation stage through their inhibitory effects on arachidonic acid metabolism and combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention. Expand
Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model
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It is shown that 5-LOX is up-regulated in adenomatous colon polyps and cancer compared with normal colonic mucosa and may prove a beneficial chemopreventive therapy in colon cancer. Expand
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  • 2021
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TLDR
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