Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease.

@article{Canda2012OverexpressionO1,
  title={Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease.},
  author={Roberto Cand{\'i}a and A Mart{\'i}nez Riquelme and Rene F Baudrand and Cristian Carvajal and Mauricio Ota{\'i}za Morales and Nancy Sol{\'i}s and Margarita Pizarro and A. Sendin Escalona and Gonzalo Carrasco and Camilo Boza and Gustavo P{\'e}rez and Oslando Padilla and Jaime Cerd{\'a} and Carlos E. Fardella and Marco Arrese},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2012},
  volume={32 3},
  pages={392-9}
}
BACKGROUND The enzyme 11β-hydroxysteroid-dehydrogenase type 1 (11β-HSD1) catalyses the reactivation of intracellular cortisol. We explored the potential role of 11β-HSD1 overexpression in visceral adipose tissue (VAT) in non-alcoholic fatty liver disease (NAFLD) assessing sequential changes of enzyme expression, in hepatic and adipose tissue, and the occurrence of portal hypercortisolism in obese mice. 11β-HSD1 expression was also assessed in tissues from obese patients undergoing bariatric… CONTINUE READING

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