Overexpression of αvβ6 integrin alters the colorectal cancer cell proteome in favor of elevated proliferation and a switching in cellular adhesion that increases invasion.

@article{Cantor2013OverexpressionO,
  title={Overexpression of αvβ6 integrin alters the colorectal cancer cell proteome in favor of elevated proliferation and a switching in cellular adhesion that increases invasion.},
  author={David I Cantor and Iveta Slapetov{\'a} and Alison Kan and Leon R. McQuade and Mark S Baker},
  journal={Journal of proteome research},
  year={2013},
  volume={12 6},
  pages={2477-90}
}
Many proteins enhance cancer progression toward life-threatening metastases. These include linking proteins called integrins that mediate cell adhesion to the extracellular matrix (ECM), consequently altering both function and phenotype. Specific neoexpression of the β6 integrin subunit correlates with the epithelial-to-mesenchymal transition, metastasis, and poor overall patient survival. While β6 is implicated in these processes, exactly how it affects signaling and/or proteolytic pathways in… CONTINUE READING
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