Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma

  title={Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma},
  author={Anne Tallet and J-C Nault and Annie Renier and Ilir Hysi and Françoise B Galateau-Sall{\'e} and Alex Cazes and M-C Copin and P. Hofman and Pascal Andujar and Françoise Le Pimpec-Barthes and Jessica Zucman-Rossi and M-C Jaurand and Didier Jean},
Malignant pleural mesothelioma (MPM) is a very aggressive tumor with no known curative treatment. Better knowledge of the molecular mechanisms of mesothelial carcinogenesis is required to develop new therapeutic strategies. MPM, like all cancer cells, needs to maintain telomere length to prevent senescence. Previous studies suggested that the telomere lengthening mechanism in MPM is based mainly on telomerase activity. For this reason, we focused on the key catalytic enzyme, TERT (telomerase… CONTINUE READING
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