Overexpression and knockout of miR-126 both promote leukemogenesis.

@article{Li2015OverexpressionAK,
  title={Overexpression and knockout of miR-126 both promote leukemogenesis.},
  author={Zejuan Li and Ping Ping Chen and Rui Su and Yuanyuan Li and Chao Hu and Yungui Wang and Stephen Arnovitz and Miao He and Sandeep K Gurbuxani and Zhixiang Zuo and Abdel G. Elkahloun and Shenglai Li and Hengyou Weng and Hao Huang and Mary Beth Neilly and Shusheng Wang and Eric N Olson and Richard A Larson and Michelle M Le Beau and Jiwang Zhang and Xi Jiang and Min-jie Wei and Jie Jin and Paul P. Liu and Jianjun Chen},
  journal={Blood},
  year={2015},
  volume={126 17},
  pages={2005-15}
}
It is generally assumed that gain- and loss-of-function manipulations of a functionally important gene should lead to the opposite phenotypes. We show in this study that both overexpression and knockout of microRNA (miR)-126 surprisingly result in enhanced leukemogenesis in cooperation with the t(8;21) fusion genes AML1-ETO/RUNX1-RUNX1T1 and AML1-ETO9a (a potent oncogenic isoform of AML1-ETO). In accordance with our observation that increased expression of miR-126 is associated with unfavorable… CONTINUE READING
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Osteoblastderived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

  • HC Tai, AC Chang, HJ Yu
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