Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer

@article{Miao2012OverexpressionAC,
  title={Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer},
  author={Yuan Miao and Liang Wang and Yang Liu and Ai-lin Li and Shu-li Liu and Hong-Yi Cao and Xiupeng Zhang and Guiyang Jiang and Di Liu and En-Hua Wang},
  journal={Tumor Biology},
  year={2012},
  volume={34},
  pages={107-114}
}
Hepl, first described in 2008, is the fourth member of the Crk-associated substrate (CAS) family and is specifically expressed in the lung. Compared to other CAS proteins, Hepl has a varying effect on cell migration in different cell types. We speculated that Hepl may play a role in lung cancer invasion and metastasis. We quantified the expression and subcellular localization of Hepl in 143 non-small cell lung cancer (NSCLC) tissues, adjacent noncancerous tissues, and eight lung cancer cell… Expand
The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit
TLDR
In the microenvironment of lung adenocarcinoma, the differentially expressed genes screened by immune score and stromal score have certain value in evaluating the survival/prognosis of patients, as well as the invasion and progression of tumors. Expand
Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
TLDR
Overall, the findings show how mislocalization of TMEM88 to the cytosol in NSCLC cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3β-Snail signaling pathway. Expand
Overexpression of CASS4 promotes invasion in non-small cell lung cancer by activating the AKT signaling pathway and inhibiting E-cadherin expression
TLDR
The present results indicate that CASS4 may promote NSCLC invasion by activating the AKT signaling pathway, thereby inhibiting E-cadherin expression. Expand
New advances of TMEM88 in cancer initiation and progression, with special emphasis on Wnt signaling pathway
TLDR
Current knowledge on the functional role and potential clinical application of TMEM88, a newly discovered protein localized on the cell membrane, and its role in the control of various cancers are reviewed. Expand
CAS proteins in health and disease: An update
TLDR
An update on recently published studies describing signals regulating and regulated by CAS proteins, and evidence for biological activity of CAS proteins in normal development, cancer, and other pathological conditions is provided. Expand
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
TLDR
This review summarizes the current understanding of EFS and CASS4 protein function in the context of the larger CAS family group, and indicates they conserve many elements with the better-known family members. Expand
Molecular determinants of astrocyte morpho-functional changes in Alzheimer’s disease
TLDR
It is demonstrated that the Cas-family proteins, previously identified by GWAS as genetic risk-factors for late-onset AD, NEDD9 and CASS4 act as regulators of astrocyte morphology and may therefore contribute to astroCyte pathology in AD. Expand

References

SHOWING 1-10 OF 29 REFERENCES
A novel Cas family member, HEPL, regulates FAK and cell spreading.
TLDR
The human HEPL mRNA and protein are selectively expressed in specific primary tissues and cancer cell lines, and HEPL maintains Cas family function in localization to focal adhesions, as well as regulation of FAK activity, focal adhesion integrity, and cell spreading. Expand
CAS proteins in normal and pathological cell growth control
TLDR
This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade. Expand
NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation
TLDR
It is established that Cas proteins negatively regulate E-cadherin expression in human mammary cells, and a new role for Cas proteins in cell-cell adhesion signaling in cancer is suggested. Expand
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells
TLDR
It is suggested that HEF1 acts as a necessary and specific downstream effector of FAK in the invasive behavior of glioblastoma cells and may be an effective target for treatment of these tumors. Expand
Aberrant responsiveness to RANTES in synovial fluid T cells from patients with rheumatoid arthritis.
TLDR
Synovial fluid T cells highly positive for CCR5 show aberrant characteristics; resistant to RANTES in terms of migration, but responsive in terms-of-life dynamics of C CR5. Expand
Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells
TLDR
Multiple CAS-mediated signaling events are implicated in promoting invasive and metastatic properties of Src-transformed cells. Expand
Deficiency in Expression of the Signaling Protein Sin/Efs Leads to T-Lymphocyte Activation and Mucosal Inflammation
TLDR
It is shown that Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production and that immune system dysfunction in the absence of Sin may underlie the pathogenesis of tissue-specific inflammation and enteropathies such as CD. Expand
Updated staging system for lung cancer.
  • P. Goldstraw
  • Medicine
  • Surgical oncology clinics of North America
  • 2011
TLDR
There have been changes to certain tumor and metastasis descriptors and the resultant stage groupings in the seventh edition of TNM for Lung Cancer. Expand
Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance1
TLDR
It is found that lymphocyte trafficking was altered in Cas-L-deficient mice, which gave a potential reason for contraction of secondary lymphoid tissues and affects homeostasis of MZB cells and peripheral lymphoid organs. Expand
...
1
2
3
...