Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme

@article{Mukherjee2014OverexpressionAC,
  title={Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme},
  author={Malini Mukherjee and Tiara T. Byrd and Vita S. Brawley and Kevin J Bielamowicz and Xiao-Nan Li and F. Merchant and Saurabh Maitra and Pavel Sumazin and Greg N. Fuller and Yvonne Kew and David Sun and Suzanne Zein-Eldin Powell and Nabil M. Ahmed and Nenggang Zhang and Debananda Pati},
  journal={Journal of Neuro-Oncology},
  year={2014},
  volume={119},
  pages={27-35}
}
Separase, an enzyme that cleaves the chromosomal cohesin during mitosis, is overexpressed in a wide range of human epithelial cancers of breast, bone and prostate (Meyer et al., Clin Cancer Res 15(8):2703–2710, 2009). Overexpression of Separase in animal models results in aneuploidy and tumorigenesis. We have examined the expression and localization of Separase protein in adult and pediatric glioblastoma and normal brain specimens. Immunofluorescence microscopy and Western blot analysis showed… CONTINUE READING
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