Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers

@article{Singh2008OverexpressionAH,
  title={Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers},
  author={Purnima Singh and Ming Yang and Huifang Dai and Dianke Yu and Qin Huang and Wen Tan and Kemp H. Kernstine and Dongxin Lin and Binghui Shen},
  journal={Molecular Cancer Research},
  year={2008},
  volume={6},
  pages={1710 - 1717}
}
Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA fragmentation. Functional deficiencies in FEN1, in the forms of somatic mutations and polymorphisms, have recently been shown to lead to autoimmunity, chronic inflammation, and predisposition to and progression of cancer. To explore how FEN1 contributes to cancer progression, we examined FEN1 expression using 241 matched pairs of… 

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