Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

  title={Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.},
  author={Camille Ehr{\'e} and Erin N Worthington and Rachael M. Liesman and Barbara R. Grubb and Diane Barbier and Wanda K. O'Neal and Jean-Michel Sallenave and Raymond J. Pickles and Richard C. Boucher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 41},
MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response to infectious agents, implying that mucins exert a protective role against inhaled pathogens. However, epidemiological and pathological studies suggest that excessive mucin secretion causes airways obstruction and inflammation. To determine whether increased MUC5AC secretion alone produces airway obstruction and/or inflammation, we generated a mouse model overexpressing Muc5ac mRNA ~20-fold in… CONTINUE READING
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