Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells.

@article{Chen2002OverexpressedHM,
  title={Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells.},
  author={Yan Hai Chen and Jiyang Cai and T. J. Murphy and D. H. P. Jones},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 36},
  pages={33242-8}
}
Oxidative damage to mitochondria is a central mechanism of apoptosis induced by many toxic chemicals. Thioredoxin family proteins share a conserved Cys-X-X-Cys motif at their active center and play important roles in control of cellular redox state and protection against oxidative damage. In addition to the well studied cytosolic and extracellular form (Trx1), rat and avian mitochondrial forms of thioredoxin (mtTrx) have been reported. In this study, we cloned the full-length human mtTrx cDNA… CONTINUE READING
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