Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells.

@article{Baldassarre1999OverexpressedCD,
  title={Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells.},
  author={Gustavo Baldassarre and Barbara Belletti and Paola Bruni and Angelo Boccia and Francesco Trapasso and Francesca Pentimalli and Maria Vittoria Barone and Gennaro Chiappetta and Maria Teresa Vento and Stefania Spiezia and Alfredo Fusco and Giuseppe Viglietto},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 7},
  pages={865-74}
}
The majority of thyroid carcinomas maintain the expression of the cell growth suppressor p27, an inhibitor of cyclin-dependent kinase-2 (Cdk2). However, we find that 80% of p27-expressing tumors show an uncommon cytoplasmic localization of p27 protein, associated with high Cdk2 activity. To reproduce such a situation, a mutant p27 devoid of its COOH-terminal nuclear-localization signal was generated (p27-NLS). p27-NLS accumulates in the cytoplasm and fails to induce growth arrest in 2 different… CONTINUE READING