Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases.

@article{Taniuchi2005OverexpressedPP,
  title={Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases.},
  author={Keisuke Taniuchi and Hidewaki Nakagawa and Masayo Hosokawa and Toru Nakamura and Hidetoshi Eguchi and Hiroaki Ohigashi and Osamu Ishikawa and Toyomasa Katagiri and Yusuke Nakamura},
  journal={Cancer research},
  year={2005},
  volume={65 8},
  pages={3092-9}
}
P-Cadherin/CDH3 belongs to the family of classic cadherins that are engaged in various cellular activities including motility, invasion, and signaling of tumor cells, in addition to cell adhesion. However, the biological roles of P-cadherin itself are not fully characterized. Based on information derived from a previous genome-wide cDNA microarray analysis of microdissected pancreatic ductal adenocarcinoma (PDAC), we focused on P-cadherin as one of the genes most strongly overexpressed in the… CONTINUE READING
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