Overestimation of genetic risks owing to small sample sizes in cardiovascular studies.

@article{Morgan2003OverestimationOG,
  title={Overestimation of genetic risks owing to small sample sizes in cardiovascular studies.},
  author={Thomas M. Morgan and Christopher S. Coffey and Harlan M. Krumholz},
  journal={Clinical genetics},
  year={2003},
  volume={64 1},
  pages={
          7-17
        }
}
We sought evidence of publication bias to explain conflicting findings in studies of angiotensin-converting enzyme deletion polymorphism (ACE D) and glycoprotein IIIa PlA2 (PLA2) polymorphism and the risk of myocardial infarction. Factor 5 Leiden (F5L), a well-established thrombotic risk factor, served as an internal comparison. We conducted systematic reviews of published studies involving ACE D, PLA2, F5L and relevant outcomes, searching medline (January 1990 through February, 2001… CONTINUE READING
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