Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

@article{Poncelet2003OvereatingAA,
  title={Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.},
  author={Martine Poncelet and Jeanne Maruani and Roselyne Calassi and Philippe Soubri{\'e}},
  journal={Neuroscience letters},
  year={2003},
  volume={343 3},
  pages={216-8}
}
Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models. 

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