Overdose of Atypical Antipsychotics

@article{Levine2012OverdoseOA,
  title={Overdose of Atypical Antipsychotics},
  author={Michael Levine and Anne-Michelle Ruha},
  journal={CNS Drugs},
  year={2012},
  volume={26},
  pages={601-611}
}
Historically, treatment for schizophrenia focused on sedation. The advent of the typical antipsychotics resulted in treatment aimed specifically at the underlying disease, but these agents were associated with numerous adverse effects, and were not particularly effective at treatment of the negative symptoms of schizophrenia. As a result, numerous atypical agents have been developed over the past 2 decades, including several agents within the past 5 years.Overdose of antipsychotics remains… Expand

Paper Mentions

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References

SHOWING 1-10 OF 105 REFERENCES
New atypical antipsychotic medications.
TLDR
The drugs' unique profiles with regard to other side effects may make it possible to tailor treatment more individually to patients, and further refinement of the clinical utility of these drugs awaits their widespread use in mainstream clinical settings. Expand
Toxicology and overdose of atypical antipsychotic medications in children: does newer necessarily mean safer?
TLDR
While new atypical antipsychotics medications may have a safer therapeutic and overdose profile than first-generation antipsychotic medications, many adverse and toxic effects still need to be considered in therapeutic monitoring and overdose management. Expand
Recent Advances in the Pharmacotherapy of Schizophrenia
  • R. Borison
  • Psychology, Medicine
  • Harvard review of psychiatry
  • 1997
TLDR
Pharmacoeconomic studies comparing clozapine and risperidone to the standard neuroleptics indicate that these newer drugs appear likely to lower the overall cost of treatment for schizophrenia, primarily by reducing rates of relapse and rehospitalization. Expand
Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions.
TLDR
The main features regarding pharmacodynamics, pharmacokinetics and pharmacological interactions of the most important atypical antipsychotic agents, namely clozapine, olanzapines, quetiapine and risperidone, are treated herein. Expand
Impact of Atypical Antipsychotics on Quality of Life in Patients with Schizophrenia
TLDR
The new antipsychotic medications introduced over the last 15 years have shown themselves to be at least comparable in efficacy to conventional antipsychotics but with superior subjective tolerability and a more favourable adverse effect profile. Expand
The Pharmacology and Toxicology of Atypical Antipsychotic Agents
  • M. Burns
  • Medicine
  • Journal of toxicology. Clinical toxicology
  • 2001
TLDR
The pharmacodynamics, pharmacokinetics, and toxicology of atypical antipsychotic drugs, chiefly clozapine, risperidone, olanzapines, and quetiapine are reviewed and recommendations on management are provided. Expand
Adverse Effects of Atypical Antipsychotics
TLDR
It is concluded that broad statements comparing the relative risk of specific adverse effects between ‘atypical’ and ‘conventional’ antipsychotics are largely meaningless; rather, comparisons should be made between specific atypical and specific conventional drugs. Expand
A systematic review of cardiovascular effects after atypical antipsychotic medication overdose.
TLDR
A systematic literature review of overdoses of atypical antipsychotic medications suggests that overdose of AAPM is unlikely to cause significant cardiovascular toxicity. Expand
A Comparative Review of New Antipsychotics
  • O. Blin
  • Medicine, Psychology
  • Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1999
TLDR
A decision algorithm for comparing drugs used for psychotic disorders, based on biochemical profile, experimental pharmacology, postiron emission tomography (PET) scan results, and clinical efficacy on positive, negative, anxious, depressive, and cognitive symptoms is proposed. Expand
Antipsychotic treatment and extrapyramidal symptoms amongst schizophrenic inpatients
TLDR
No difference regarding re-hospitalization and inpatient-days was found, whether the patient was treated with typical or atypical antipsychotics, however, it is important to underline that patients treated with atypicals oral antipsychotic do as well as patients on typical depot antippsychotics. Expand
...
1
2
3
4
5
...