Overdosage of antidepressants: Clinical and pharmacokinetic aspects

  title={Overdosage of antidepressants: Clinical and pharmacokinetic aspects},
  author={O. Lindegaard Pedersen and Lars Freng Gram and Christian B. Kristensen and Mogens M\oller and Per Thayssen and Marianne Bjerre and Per Kragh-S\orensen and Niels Anders Klitgaard and E. H. Sindrup and Peter Hole and M M Brinkl\ov},
  journal={European Journal of Clinical Pharmacology},
Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24 h-ECG-monitoring, measurement of systolic time intervals, EEG recordings and frequent measurement of serum levels of antidepressants and primary metabolites. None of the patients died. Maximum total serum antidepressant level (parent compound… CONTINUE READING


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