Overcoming treatment resistance in acute promyelocytic leukemia and beyond

@article{Fung2013OvercomingTR,
  title={Overcoming treatment resistance in acute promyelocytic leukemia and beyond},
  author={T. Fung and C. So},
  journal={Oncotarget},
  year={2013},
  volume={4},
  pages={1128 - 1129}
}
From the introduction of all-trans retinoic acid (ATRA) to the recent development of arsenic trioxide (ATO) treatment, acute promyelocytic leukemia (APL) characterized by the presence of retinoic acid receptor alpha (RARA) fusion has been transformed from a highly fatal cancer to a highly curable disease. In spite of this unprecedented success, there are still a significant number of high-risk patients who fail to achieve a complete molecular remission or relapse and become resistant to the… Expand
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