Overcoming the innate immune response to small interfering RNA.

@article{Judge2008OvercomingTI,
  title={Overcoming the innate immune response to small interfering RNA.},
  author={Adam D. Judge and Ian Maclachlan},
  journal={Human gene therapy},
  year={2008},
  volume={19 2},
  pages={111-24}
}
Many types of nucleic acid, including canonical small interfering RNA (siRNA) duplexes, are potent activators of the mammalian innate immune system. Synthetic siRNA duplexes can induce high levels of inflammatory cytokines and type I interferons, in particular interferon-alpha, after systemic administration in mammals and in primary human blood cell cultures. These responses are greatly potentiated by the use of delivery vehicles that facilitate cellular uptake of the siRNA. Although the… CONTINUE READING
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