Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens.


Virtually all bacterial pathogens require iron to infect vertebrates. The most abundant source of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many bacterial pathogens have elegant systems dedicated to the acquisition of heme from host hemoproteins. Once internalized, heme is either degraded to release free iron or used… (More)
DOI: 10.1128/IAI.00613-10


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