Overcoming the funding challenge: the cost of randomized controlled trials in the next decade.


Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies… (More)
DOI: 10.2106/JBJS.L.00193


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