Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol

@article{Gallily2015OvercomingTB,
  title={Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol},
  author={R. Gallily and Z. Yekhtin and L. Hanu{\vs}},
  journal={Pharmacology \& Pharmacy},
  year={2015},
  volume={6},
  pages={75-85}
}
Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. [...] Key Method In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given…Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility.
TLDR
It is suggested that CBD BDS reduces cholinergic-mediated contractility and that this effect is modulated by transient receptor potential vanilloid type-1 in rats but not in humans, and if confirmed in vivo, could provide a pharmacologic basis to explain the efficacy of Cannabis medicines in reducing incontinence episodes in patients with multiple sclerosis. Expand
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
TLDR
Data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA. Expand
Pharmacokinetics and Pharmacodynamics of Cannabinoids
TLDR
Properties of cannabis that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, sedation, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and induction of apoptosis in cancer cells. Expand
The Medicinal Use of Cannabis and Cannabinoids—An International Cross-Sectional Survey on Administration Forms
TLDR
The survey was completed by 953 participants from 31 countries, making this the largest international survey on a wide variety of users of cannabinoid-based medicine performed so far, and in general, herbal non-pharmaceutical CBMs received higher appreciation scores by participants than pharmaceutical products containing cannabinoids. Expand
Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
TLDR
CBD is a very promising compound since it shares the typical cannabinoid beneficial effects on gut lacking any psychotropic effects, and it is evident that this compound may interact at extra‐cannabinoid system receptor sites, such as peroxisome proliferator‐activated receptor‐gamma, making it a potential candidate for the development of a new class of anti‐IBD drugs. Expand
Delta-9-Tetrahydrocannabinol/Cannabidiol (Sativex®): A Review of Its Use in Patients with Moderate to Severe Spasticity Due to Multiple Sclerosis
TLDR
In the largest multinational clinical trial that evaluated the approved THC/CBD regimen in this population, 12 weeks’ double-blind treatment with THC /CBD significantly reduced spasticity severity (primary endpoint) compared with placebo in patients who achieved a clinically significant improvement inSpasticity after 4 the authors weeks’ single-blind THC/cBD treatment, as assessed by a patient-rated numerical rating scale. Expand
Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.
TLDR
CBD BDS attenuates colon carcinogenesis and inhibits colorectal cancer cell proliferation via CB1 and CB2 receptor activation. Expand
Cannabis--a valuable drug that deserves better treatment.
TLDR
About 150 years ago, a French psychiatrist, J. Moreau, conducted a novel clinical experiment in which he administered hashish to humans and concluded that “There is not a single, elementary manifestation of mental illness that cannot be found in the mental changes caused by hashish. Expand
The effects of Δ9‐tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
TLDR
The effects of CBD and THC alone and in combination were investigated in a model of colitis to establish if these cannabinoids interact in vivo in inflammatory disorders. Expand
Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents
The Cannabis plant and its products consist of an enormous variety of chemicals. Some of the 483 compounds identified are unique to Cannabis, for example, the more than 60 cannabinoids, whereas theExpand
...
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3
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