Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.

@article{Scotlandi2009OvercomingRT,
  title={Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.},
  author={Katia Scotlandi and Daniel Remondini and Gastone Castellani and Maria Cristina Manara and Filippo Nardi and Lara Cantiani and Mirko Francesconi and M. Cristina Mercuri and Anna Maria Caccuri and Massimo Serra and Sakari Knuutila and Piero Picci},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 13},
  pages={2209-16}
}
PURPOSE The improvement of Ewing sarcoma (EWS) therapy is currently linked to the discovery of strategies to select patients with poor and good prognosis and of modified treatment regimens. In this study, we analyzed the molecular factors governing EWS response to chemotherapy to identify genetic signatures to be used for risk-adapted therapy. PATIENTS AND METHODS Microarray technology was used for profiling 30 primary tumors and seven metastases of patients who were classified according to… CONTINUE READING

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