Overcoming preexisting humoral immunity to AAV using capsid decoys.

@article{Mingozzi2013OvercomingPH,
  title={Overcoming preexisting humoral immunity to AAV using capsid decoys.},
  author={Federico Mingozzi and Xavier M Anguela and Giulia Pavani and Yifeng Chen and Robert J Davidson and Daniel J. Hui and Mustafa Yazicioglu and Liron Elkouby and Christian J Hinderer and Armida Faella and Carolann Howard and Alex Y.C. Tai and Gregory M. Podsakoff and Shangzhen Zhou and Etiena Basner-Tschakarjan and J. F. Wright and K. A. High},
  journal={Science translational medicine},
  year={2013},
  volume={5 194},
  pages={194ra92}
}
Adeno-associated virus (AAV) vectors delivered through the systemic circulation successfully transduce various target tissues in animal models. However, similar attempts in humans have been hampered by the high prevalence of neutralizing antibodies to AAV, which completely block vector transduction. We show in both mouse and nonhuman primate models that addition of empty capsid to the final vector formulation can, in a dose-dependent manner, adsorb these antibodies, even at high titers, thus… CONTINUE READING
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High , Overcoming preexisting humoral immunity to AAV using capsid decoys

  • J. F. Wright, A. K.
  • Sci . Transl . Med .
  • 2013

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