Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924.

@article{Jazaeri2013OvercomingPR,
  title={Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924.},
  author={Amir Anthony Jazaeri and Etsuko Shibata and Jonghoon Park and Jennifer Lynn Bryant and Mark R. Conaway and Susan C. Modesitt and Peter G Smith and Michael A. Milhollen and Allison J. Berger and Anindya Dutta},
  journal={Molecular cancer therapeutics},
  year={2013},
  volume={12 10},
  pages={1958-67}
}
The nearly ubiquitous development of chemoresistant disease remains a major obstacle against improving outcomes for patients with ovarian cancer. In this investigation, we evaluated the preclinical activity of MLN4924, an investigational inhibitor of the NEDD8-activating enzyme, in ovarian cancer cells. Efficacy of MLN4924 both alone and in combination with platinum was assessed. Overall, single-agent MLN4924 exhibited moderate activity in ovarian cancer cell lines. However, the combination of… CONTINUE READING