Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.

@article{Dubikovskaya2008OvercomingMR,
  title={Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.},
  author={Elena A. Dubikovskaya and Steve Thorne and Thomas H Pillow and Christopher H. Contag and Paul A Wender},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 34},
  pages={12128-33}
}
Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross-resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp)-mediated drug efflux. To address this problem, new agents have been sought that are less prone to inducing resistance and less likely to serve as substrates for Pgp efflux. An alternative to this approach is to deliver established agents as molecular transporter conjugates into cells… CONTINUE READING

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