Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors.

  title={Overcoming multidrug resistance in cancer: clinical studies of p-glycoprotein inhibitors.},
  author={Helen M. Coley},
  journal={Methods in molecular biology},
Chemotherapy remains the mainstay in the treatment and management of many cancers. However, this treatment modality is fraught with difficulties associated with toxicity and also the emergence of chemotherapy resistance is a considerable problem. Cancer scientists and oncologists have worked together for some time to find ways of understanding anticancer drug resistance and also to develop pharmacological strategies to overcome that resistance. The greatest focus has been on the reversal of the… CONTINUE READING
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